Document 0060 DOCN M9490060 TI Candidal infection of the gingiva in HIV-infected persons. DT 9411 AU Odden K; Schenck K; Koppang H; Hurlen B; Department of Oral Biology, University of Oslo, Norway. SO J Oral Pathol Med. 1994 Apr;23(4):178-83. Unique Identifier : AIDSLINE MED/94322277 AB Gingival biopsies were taken from 27 HIV (human immunodeficiency virus)-seropositive persons with gingivitis or periodontitis and 16 HIV-seronegative persons with periodontitis. Sections were stained with hematoxylin and eosin or periodic acid-Schiff. Candidal hyphae and pseudohyphae were found in the parakeratinized oral epithelium in 7 specimens from the HIV-infected patient group such specimen. No fungal invasion was found in any of the biopsies from the HIV-seronegative persons. Candidal invasion was significantly more frequent (P < 0.05) in patients with a confirmed history of necrotizing periodontal diseases (5/9) than in patients without known episodes of such diseases (3/18). The most prominent histopathologic changes observed in connection with candidal invasion comprised polymorphonuclear leucocyte infiltration of the oral gingival epithelium and numerous mitoses, some of which were located suprabasally. It is suggested that Candida albicans may contribute to the development of necrotizing periodontal diseases in HIV-infected persons. DE Adult AIDS-Related Opportunistic Infections/*PATHOLOGY Candida/GROWTH & DEVELOPMENT Candidiasis, Oral/*PATHOLOGY Connective Tissue/PATHOLOGY Epithelium/PATHOLOGY Female Gingiva/MICROBIOLOGY/PATHOLOGY Gingival Hemorrhage/MICROBIOLOGY/PATHOLOGY Gingivitis/*MICROBIOLOGY/PATHOLOGY Human HIV Infections/*PATHOLOGY HIV Seronegativity Male Middle Age Necrosis Neutrophils/PATHOLOGY Periodontitis/MICROBIOLOGY/PATHOLOGY Ulcer/MICROBIOLOGY/PATHOLOGY JOURNAL ARTICLE SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).